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Влияние предшественника лей-энкефалина на активность ферментов обмена регуляторных пептидов головного мозга и периферических органов крыс в норме и при эмоционально-болевом стрессе

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ПРИЛОЖЕНИЕ

Таблица 1. Активность КПН, ФМСФ-ингибируемой КП и АПФ у интактных животных (нмоль продукта, образовавшегося за 1 мин инкубации на 1 мг белка, М m, n = 5-6, здесь и в таблицах 2-7: Г - гипофиз, СМ - средний мозг, ГТ - гипоталамус, ГК - гиппокамп, СТ - стриатум, БП - большие полушария, НП - надпочечники, СЕ - семенники)

Отделы мозга, органы

КПН

ФМСФ -

ингибируемая КП

АПФ

M±m

M±m

M±m

Г

1,54±0,01

1,36±0,08

0,53±0,06

СМ

0,22±0,02

0,31±0,03

0,05±0,02

ГТ

0,24±0,02

0,33±0,03

0,06±0,01

ГК

0,28±0,03

0,33±0,03

0,01±0,001

СТ

0,18±0,01

0,34±0,03

0,19±0,03

БП

0,18±0,01

0,35±0,02

0,03±0,01

НП

0,1±0,02

1,84±0,1

0,01±0,01

СЕ

0,06±0,01

0,3±0,04

0,53±0,03

Таблица 2. Активность КПН, ФМСФ-ингибируемой КП и АПФ в мозге и тканях крыс при воздействии острого ЭБС (нМ продукта, образовавшегося за 1 мин инкубации на 1 мг белка, М±m, n=5, *- p<0,05, **- p<0,01, ***- p<0,001 к норме, здесь и в таблицах 3-7: I - отдел мозга, орган, II - время после начала воздействия)

I

II

КПН

ФМСФ-инг. кп

АПФ

норма

ЭБС

норма

ЭБС

норма

ЭБС

Г

0,5 ч.

4 ч.

24 ч.

72 ч.

240 ч.

1,54±0,08

2,2±0,23**

1,87±0,1*

2,02±0,08**

2,37±0,12***

1,39±0,05

1,36±0,07

1,18±0,14

1,26±0,06

1,46±0,06

1,67±0,05**

1,45±0,07

0,53±0,06

0,48±0,03

0,38±0,06**

0,53±0,05

0,58±0,04

0,46±0,04

СМ

0,5 ч.

4 ч.

24 ч.

72 ч.

240 ч.

0,22±0,01

0,23±0,01

0,18±0,01*

0,22±0,01

0,22±0,01

0,21±0,01

0,31±0,02

0,27±0,02

0,29±0,01

0,3±0,02

0,37±0,01*

0,34±0,02

0,05±0,02

0,05±0,01

0,02±0,01

0,02±0,01

0,04±0,01

0,02±0,01

ГТ

0,5 ч.

4 ч.

24 ч.

72 ч.

240 ч.

0,24±0,02

0,28±0,02

0,20±0,01

0,24±0,01

0,27±0,03

0,23±0,02

0,33±0,01

0,31±0,02

0,31±0,01

0,32±0,02

0,4±0,01**

0,34±0,01

0,06±0,01

0,01±0,01

0,03±0,0,1

0,02±0,01

0,04±0,01

0,04±0,01

ГК

0,5 ч.

4 ч.

24 ч.

72 ч.

240 ч.

0,28±0,03

0,26±0,01

0,19±0,01**

0,27±0,01

0,29±0,02

0,25±0,02

0,33±0,02

0,29±0,01

0,32±0,01

0,35±0,03

0,42±0,02**

0,34±0,01

0,01±0,01

0,04±0,02

0,02±0,01

0,01±0,01

0,04±0,01

0,03±0,01

СТ

0,5 ч.

4 ч.

24 ч.

72 ч.

240 ч.

0,18±0,01

0,18±0,02

0,2±0,01

0,26±0,01**

0,24±0,03*

0,18±0,01

0,34±0,03

0,31±0,03

0,33±0,02

0,32±0,01

0,4±0,02

0,34±0,01

0,19±0,02

0,13±0,02

0,15±0,01**

0,15±0,01

0,18±0,02

0,19±0,01

БП

0,5 ч.

4 ч.

24 ч.

72 ч.

240 ч.

0,18±0,02

0,21±0,01

0,18±0,02

0,19±0,01

0,24±0,01*

0,198±0,01

0,35±0,02

0,32±0,01

0,35±0,01

0,34±0,01

0,55±0,01***

0,37±0,03

0,03±0,01

0,02±0,01

0,01±0,00

0,01±0,00

0,02±0,01

0,01±0,00

НП

0,5ч

24ч

72ч

240ч

0,1±0,02

0,08±0,01

0,06±,002

0,06±0,02

0,09±0,01

0,1±,02

1,84±0,05

1,72±0,09

1,62±0,05*

1,46±0,09**

2,88±0,04**

1,75±0,02

0,01±0,01

0,02±0,01

0,03±0,01

0,02±0,01

0,01±0,01

0,02±0,02

СЕ

0,5ч

24ч

72ч

240ч

0,06±0,01

0,07±0,01

0,07±0,02

0,07±0,02

0,05±0,01

0,06±0,01

0,3±0,02

0,45±0,01*

0,3±0,01

0,31±0,02

0,27±0,01

0,25±0,02

0,53±0,03

0,59±0,01*

0,45±0,03*

0,47±0,01***

0,41±0,01

0,51±0,02

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